Somatic maintenance impacts the evolution of mutation rate
نویسندگان
چکیده
منابع مشابه
Evolution of the mutation rate.
Understanding the mechanisms of evolution requires information on the rate of appearance of new mutations and their effects at the molecular and phenotypic levels. Although procuring such data has been technically challenging, high-throughput genome sequencing is rapidly expanding knowledge in this area. With information on spontaneous mutations now available in a variety of organisms, general ...
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A recent study of X-chromosome and autosome genes in mammals suggests that selective trade-offs are important in the long-term evolution of mutation rates; but recent studies with bacteria show that high mutation rates can nonetheless evolve in the short term in clonal populations.
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15 صفحه اولA quantitative measurement of the human somatic mutation rate.
The mutation rate (mu) is a key biological feature of somatic cells that determines risk for malignant transformation, and it has been exceedingly difficult to measure in human cells. For this purpose, a potential sentinel is the X-linked PIG-A gene, because its inactivation causes lack of glycosylphosphatidylinositol-linked membrane proteins. We previously found that the frequency (f) of PIG-A...
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ژورنال
عنوان ژورنال: BMC Evolutionary Biology
سال: 2019
ISSN: 1471-2148
DOI: 10.1186/s12862-019-1496-y